Nature Is Speaking – Are We Listening?

Nature Does Not Need Us
We Need Nature
Pass It Along
🌎🌳🌞🌊

In the video above, Julia Roberts narrates a powerful message about planet Earth., Mother Earth, Gaia. Seeing these images and hearing these words really helps to put things into perspective for all of us.

While many of us may take it for granted, the planet we live on is the very foundation of all life as we know it. Home to between 10-14 million species of life, we share this planet with billions of others that have an equal stake in maintaining the planet.

For this reason, many have come to be more mindful about the impact we have on our life forms and their natural habitats. Issues such as deforestation, air/water/food contamination, weather modification, 5G EMF towers and satellites, just to name a few… have a significant impact on the quality of life for everyone living here. In many cases, this can become an issue of life or death.

Nature Does Not Need Us
We Need Nature
Pass It Along
🌎🌳🌞🌊

Can you IMAGINE your CELLS working like they did when you were young and strong?

ASEA redox VIA bottle caps complete cell wellness

Can You IMAGINE . . .?

  • Your cells working like they did when you were young and strong?
  • Daily challenges that people have been dealing with for years, now gone?
  • Athletic performance, endurance & recovery better than ever before?
  • Smoother, softer, more elastic, hydrated & healthier skin?
  • Your DNA and genetic pathways are turned on again?
  • Learning about this cellular regeneration technology NOW?

The human body is constantly working to maintain cellular health. It does this by balancing reactive molecules to rid the body of harmful components and to clean up the oxidative stress and free radical damage that occur at the cellular level. When these reactive molecules are in the proper balance, the immune system and healing process function at their optimal level. [ When you address chronic inflammation using pills and needles, this creates even more damage and disrupts cellular communication. ]

Every day more research and published articles are appearing about this “Redox Signaling” process, making it one of the fastest growing research fields in science. ASEA is the first and only stable, perfectly balanced mixture of these Redox Signaling reactive molecules that exists outside the body, and can be used to help maintain proper balance inside the body to support the immune system and healing process.

Dr. Gary L. Samuelson, Ph.D. Atomic Medical Physics, author of “The Science of Healing Revealed, New Insights into Redox Signaling” writes:

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Click image to enlarge


the science of healing revealed cover dr gary l samuelson

To get your FREE COPY of Dr. Gary L. Samuelson’s “The Science of Healing Revealed, New Insights into Redox Signaling”, email me now.

.


Dr Gary Samuelson PhD. Explains Redox Signaling Molecules

ASEA is a very unique and impressive biotech cellular research and development company that continues to push the boundaries of what’s possible in the cellular and epigenetic health category.

Since its launch, ASEA has enjoyed burgeoning success and today operates in 35+ international markets. 10 years since its founding, ASEA is profitable and financially strong. In 2015, Direct Selling News named ASEA one of the top 100 direct sales companies in the world. In 2018 ASEA surpassed the $100 Million+  mark, ($125 Mil) as it entered it’s pre-momentum growth phase.  As of July 1st, 2019 ASEA reports sales at $106 Million, on track to hit $200 Million by end of year. Conservative forecasts by experts see it doubling every year for the next 3 to 5, crossing the $1 Billion Sales mark.


“We are at the very beginning of a HUGE SHIFT in molecular cellular health with redox signaling molecules and technology. The race to create these NATIVE molecules outside our body has crossed the finish line. It is being compared to introducing electricity to someone that only understands candles. A Transformational Breakthrough for all living systems. And as with all breakthrough’s in history, the opportunity associated is HUGE!”
Bob Beliveau


REDOX Breakthrough Opportunity:
Health, Anti-Aging, Athletic, DNA, Genetic & Human Performance

6 REASONS To Take Your ASEA REDOX & RENU 28
— Dr. David Silverman

GO HERE FOR MORE INFO ON The Redox Signaling Story

Related:
Glutathione – The Master Of All Antioxidants
Redox Signaling and Inflammation
The Human Body and Redox Signaling

Glutathione – Your Body’s Master Of All Antioxidants

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Glutathione is The Master of all antioxidants, the most important molecule you need to stay healthy and prevent disease — yet you may have never heard of it. It’s the secret to preventing cellular breakdown, heart disease, aging, dementia, and neurological issues, while also increasing energy, providing quicker recovery, athletic performance and endurance, improved quality of sleep – even smoother, younger looking skin.

This single molecule of glutathione has been studied in great depth, (more than 89,000 medical articles), yet most of us know very little about it. And your doctor most likely doesn’t know how to address the epidemic deficiency of this critical life-giving molecule … (Until now… more on that in just a bit.)

What is it? I’m talking about the mother of all antioxidants, the master detoxifier and conductor of the immune system: GLUTATHIONE (pronounced “gloota-thigh-own”).

Although your body does make some of its own glutathione, things like poor food quality, pollution, toxic environments, stress, infections, and radiation are depleting it from our bodies. And as we age, our bodies continue to make less and less, overloading and damaging our liver, making it unable to do its job of detoxification.

What is Glutathione?

Glutathione is a simple molecule produced naturally in the body at all times. It’s a combination of three simple building blocks of protein or amino acids — cysteine, glycine, and glutamine.

The power of glutathione is that it contains sulfur chemical groups, that work to collect all the bad things in our body, like free radicals, toxins like mercury and other heavy metals. Sulfur is a sticky, smelly molecule. It acts like super fly paper. Once these toxic wastes are collected by glutathione, they are safely flushed into the bile and the stool, so they can be properly eliminated out of the body. This is especially important in our world today, as humanity faces unprecedented levels of using heavy environmental and industrial chemicals, pesticides and pollution.

Normally glutathione is recycled in the body — except when the toxic load becomes too great. And that explains why we are in such trouble today.

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Glutathione: Antioxidant Superhero

It also helps us reach peak mental and physical function. Research has shown that raised glutathione levels decrease muscle damage, reduce recovery time, increase strength and endurance and shift metabolism from fat production to muscle development. See this recent segment on The Doctor Oz Show.

Where Can You Get Glutathione?

Our body’s makes it, but it’s often not enough to combat our strenuous environment. It’s derived from dietary proteins, such as beef, fish and poultry. There are vegetarian sources of sulfur as well, such as cruciferous vegetables (like broccoli, brussel sprouts, cauliflower, spinach, kale, collards, cabbage watercress, mustard greens, and similar green leaf vegetables). Other good food sources that either contain glutathione or its precursors to help the body produce more include: asparagus, avocados, garlic, onions, tomatoes, peas, red peppers, peaches, watermelon, cinnamon, cardamom, turmeric (curcumin) to name a few.

Glutathione production also increases when you exercise, so increasing your activity level will help as well. Regular exercise not only makes you feel good afterwards, the activity of breathing and sweating are great ways to get rid of waste and toxins locked up in the body.

Glutathione Protects Against Illness

What makes glutathione so important and powerful is that it recycles antioxidants. When your body is dealing with free radicals, it is essentially passing them from one molecule to another. They might go from vitamin C to vitamin E to lipoic acid and then to glutathione where they are cooled off. Antioxidants are recycled at this point and the body can then regenerate another glutathione molecule to go back at it again.

Glutathione is crucial for helping your immune system fight chronic illness, as it acts as the carrier of toxins out of your body. Like a fly trap, toxins stick to glutathione and they are carried to the bile into the stools and out of the body. The body is going to come in contact with oxidants and toxins, and the more we can deal with them the better our body will be at staying strong and healthy.

9 Tips To Maximize Glutathione In Your Body

Here are 9 ways to increase your glutathione levels in your cells.

1. Consume sulfur-rich foods. The main ones in the diet are garlic, onions and the cruciferous vegetables (broccoli, kale, collards, cabbage, cauliflower, watercress, etc.).

2. Exercise boosts your glutathione levels and thereby helps boost your immune system, improve detoxification, and enhance your body’s own antioxidant defenses. Start slow and build up to 30 minutes a day of vigorous aerobic exercise like walking or jogging, or play various sports. Strength training for 20 minutes 3 times a week is also helpful.

3. Take the Redox Cell Signaling supplement called ASEA for AT LEAST 90-120 days. It’s bio-active redox signaling molecules are 100% native to our body and are very unique in that they are antioxidant activators and immune system communicators, among other things. This redox signaling technology significantly improves the body’s ability to produce glutathione – the body’s super master antioxidant – by over 500% as reported in clinical studies.

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Personally, I observed improvements in the first two weeks of taking ASEA, and I continue having improvements in the quality of my deep sleep, daytime energy, stamina, mental sharpness and focus, exercise recovery and improvements in some aging skin problems too. It’s quite fascinating really.

Summary of benefits of this breakthrough in cellular health science:

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Glutathione, SOD and Catalase Production Boosted By 500%+

One would think it would be easy just to take glutathione as a pill, but the body digests protein – so you wouldn’t get the benefits if you did it this way. However, the production and recycling of glutathione in the body requires many different nutrients which you can take. Here are some supplements you may also consider to boost glutathione, in addition to the redox signaling supplement.

4. N-acetyl-cysteine. This has been used for years to help treat asthma and lung disease and to treat people with life-threatening liver failure from Tylenol overdose. It is even given to prevent kidney damage from dyes used during x-ray studies.

5. Alpha lipoic acid. This is a close second to glutathione in importance in our cells and is involved in energy production, blood sugar control, brain health, and detoxification. The body usually makes it, but given all the stresses we are under, we often become depleted.

6. Methylation nutrients. Methylation and the production and recycling of glutathione are the two most important biochemical functions in your body. Take folate (especially in the active form of 5 methyltetrahydrofolate), B6 (in the active form of P5P), and B12 (in the active form of methylcobalamin).

7. Selenium. This important mineral helps the body recycle and produce more glutathione.

8. A family of antioxidants including vitamins C and E (in the form of mixed tocopherols) work together to recycle glutathione.

9. Milk thistle (silymarin) has long been used in treating liver disease and helps boost glutathione levels.

Related:
Can you IMAGINE your CELLS working like they did when you were young and strong?
ASEA Redox Signaling For Cellular Health
Sources:
What is Glutathione and How Do I Get More of It?
http://articles.mercola.com/sites/articles/archive/2010/04/10/can-you-use-food-to-increase-glutathione-instead-of-supplements.aspx http://www.webmd.com/vitamins-supplements/ingredientmono-717-GLUTATHIONE.aspx?activeIngredientId=717&activeIngredientName=GLUTATHIONE
Image

Can Anxiety & Stress Change Our Perception?

If you experience anxiety do this now

anxiety take deep breaths sync geometry health wisdom.gif


 

To change ourselves effectively,
we must change our perceptions.

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The Psoas: Muscle of The Soul

psoas

I was delighted when I first came across Liz Koch’s amazing work because it confirmed much of what I’d been intuiting on my own. I had begun to open and close my yoga practise with hip opening poses with the specific intention of releasing tension in my psoas and hip flexors. I’d breathe and imagine tension flowing out of constricted muscles to be released as energy into the torso.

It worked, I’d feel my body soften yet somehow grow stronger.

Reading Liz Koch I instantly realized what I was doing – by learning to relax my psoas I was literally energizing my deepest core by reconnecting with the powerful energy of the earth. According to Koch, the psoas is far more than a core stabilizing muscle; it is an organ of perception composed of bio-intelligent tissue and “literally embodies our deepest urge for survival, and more profoundly, our elemental desire to flourish.”

Well, I just had to learn more. Here is just a sprinkling of the research that Liz Koch and others have uncovered regarding the importance of the psoas to our health, vitality and emotional well-being.

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The Psoas muscle (pronounced so-as) is the deepest muscle of the human body affecting our structural balance, muscular integrity, flexibility, strength, range of motion, joint mobility, and organ functioning.

Growing out of both sides of the spine, the psoas spans laterally from the 12th thoracic vertebrae (T12) to each of the 5 lumbar vertebrae. From there it flows down through the abdominal core, the pelvis, to attach to the top of the femur (thigh) bone.

The Psoas is the only ‘muscle’ to connect the spine to the legs.  It is responsible for holding us upright, and allows us to lift our legs in order to walk. A healthily functioning psoas stabilizes the spine and provides support through the trunk, forming a shelf for the vital organs of the abdominal core.

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The psoas is connected to the diaphragm through connective tissue or fascia which affects both our breath and fear reflex. This is because the psoas is directly linked to the reptilian brain, the most ancient interior part of the brain stem and spinal cord.  As Koch writes “Long before the spoken word or the organizing capacity of the cortex developed, the reptilian brain, known for its survival instincts, maintained our essential core functioning.”

Koch believes that our fast paced modern lifestyle (which runs on the adrenaline of our sympathetic nervous system) chronically triggers and tightens the psoas – making it literally ready to run or fight. The psoas helps you to spring into action – or curl you up into a protective ball.

If we constantly contract the psoas to due to stress or tension , the muscle eventually begins to shorten leading to a host of painful conditions including low back pain, sacroiliac pain, sciatica, disc problems, spondylolysis, scoliosis, hip degeneration, knee pain, menstruation pain, infertility, and digestive problems.

psoas-problem-areas.jpgA tight psoas not only creates structural problems, it constricts the organs, puts pressure on nerves, interferes with the movement of fluids, and impairs diaphragmatic breathing.

In fact, “The psoas is so intimately involved in such basic physical and emotional reactions, that a chronically tightened psoas continually signals your body that you’re in danger, eventually exhausting the adrenal glands and depleting the immune system.”

And according to Koch, this situation is exacerbated by many things in our modern lifestyle, from car seats to constrictive clothing, from chairs to shoes that distort our posture, curtail our natural movements and further constrict our psoas.

Koch believes the first step in cultivating a healthy psoas is to release unnecessary tension.  But “to work with the psoas is not to try to control the muscle, but to cultivate the awareness necessary for sensing its messages.  This involves making a conscious choice to become somatically aware.”

dakini-psoas-core-relax-activate.jpgA relaxed psoas is the mark of play and creative expression.  Instead of the contracted psoas, ready to run or fight, the relaxed and released psoas is ready instead to lengthen and open, to dance. In many yoga poses (like tree)  the thighs can’t fully rotate outward unless the psoas releases. A released psoas allows the front of the thighs to lengthen and the leg to move independently from the pelvis, enhancing and deepening the lift of the entire torso and heart.

Koch believes that by cultivating a healthy psoas, we can rekindle our body’s vital energies by learning to reconnect with the life force of the universe. Within the Taoist tradition the psoas is spoken of as the seat or muscle of the soul, and surrounds the lower “Dan tien” a major energy center of body.  A flexible and dan-tien-psoas.jpgstrong psoas grounds us and allows subtle energies to flow through the bones, muscles and joints.

Koch writes “The psoas, by conducting energy, grounds us to the earth, just as a grounding wire prevents shocks and eliminates static on a radio. Freed and grounded, the spine can awaken”…“ As gravitational flows transfer weight through bones, tissue, and muscle, into the earth, the earth rebounds, flowing back up the legs and spine, energizing, coordinating and animating posture, movement and expression. It is an uninterrupted conversation between self, earth, and cosmos.”

So, it might be worth it, next time you practice, to tune in and pay attention to what your bio-intelligent psoas has to say.

Related:
Can you IMAGINE your CELLS working like they did when you were young and strong?
Glutathione – The Master Of All Antioxidants
ASEA Redox Signaling For Cellular Health
Natural Remedies For Muscles, Tendons, Ligaments and Bones
Source: Danielle Prohom Olson

New “Drinkable Book” Has Pages That Turn Raw Sewage Into Drinking Water

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An insatiable thirst for clean water. (Reuters/Thomas Mukoya)

As many as 358 million people in sub-Saharan Africa do not have reliable access to drinking water. Now, researchers have come up with a book on water safety whose pages can be used to filter water.

Trials done in 25 contaminated water sites in South Africa, Ghana, Kenya, Haiti, and Bangladesh showed the book, which contains tiny particles of copper and silver, could eliminate over 99% of bacteria, according to results of the project unveiled at the American Chemical Society’s national meeting that began yesterday (Aug. 16th).


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Theresa Dankovich, Ph.D., from Carnegie Mellon in Pittsburgh, who has been leading the research on what she calls “the drinkable book” said in one trial, they tested a ditch contaminated with sewage that contained millions of bacteria. “Even with highly contaminated water sources like that one, we can achieve 99.9% purity with our silver-and copper-nanoparticle paper, bringing bacteria levels comparable to those of US drinking water,” Dankovicz said.

Each page is embedded with silver and copper nano-particles. The pages contain instructions in English and the local language; water is poured and filtered through the pages themselves. One page can purify up to 100 liters (about 26 gallons) of water and one book can supply one person’s drinking water needs for about four years, the researchers said


The researchers currently make the books by hand themselves—but are now looking to ramp up production and send the books to local communities.

Sign up for the World Class Wellness Newsletter and receive helpful how-to’s, tips and advice to make your life more healthy, self-sustaining and successful.

Disturbing things that happen to your body when you drink Coca-Cola

A new infographic that’s trending in social media today claims to explain exactly why you feel a drug-like rush when Coca-Cola enters your system.

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Your body in the hour after drinking a can of Coca-Cola. [click to view full size]

With step-by-step descriptions, the infographic reveals what happens to your body in the hour after drinking one can of Coke, though the information applies to any caffeinated soft drink.

The content is based on research conducted by health writer Wade Meredith who wanted to know how the body reacts to a massive dose of caffeine and sugar:

  • One serving of Coke contains 10 teaspoons of sugar, and in the first 10 minutes, Meredith explains, “You don’t immediately vomit from the overwhelming sweetness because phosphoric acid cuts the flavor allowing you to keep it down.”
  • In the following 20 minutes, your liver responds to the sugar spike “by turning any sugar it can get its hands on into fat.”
  • By 40 minutes, Meredith explains, “caffeine absorption is complete,” causing pupils to dilate, blood pressure to rise, and the liver to dump more sugar into your bloodstream.
  • By 45 minutes, you’re feeling pretty high as your body kicks up dopamine production, stimulating the pleasure centers of your brain. “This is physically the same way heroin works, by the way,” Meredith shares.
  • Finally, a sugar crash hits at about the 60-minute mark, and “the rave inside of you dies down.”

Some 1.6 billion servings of Coke are sold worldwide each day. Many people drink regular and diet caffeinated soft drinks daily. Meredith’s infographic might make some of these people realize that Coke can bring you a smile but it also wreaks havoc on your body.


Here are some great healthy alternatives to consider:

Ten4 Energy Drink
PiMag Water

Related:
How Acidic Foods Affect Your Body Over Time
Know These 7 Symbols On Plastic That May Poison You
Video: What Happens In Your Body When You Eat Processed Foods
7 Habits Of Highly Miserable & Unhealthy People

 

What Are The Perks Of Working From Home? [INFOGRAPHIC]

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It’s Sunday, so you may be catching up with some work. But do you work from home during the week?

What are the perks of working from your front room or home office? Read them below. (via CarInsurance.org)

Takeaways:

• Cutting the commute helps the environment.
• Extra time out of the car is only a good thing!
• Employees who work at home are happier.

RELATED: Working From Home: Is It the Future?

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For more information on great perks from working at home,
see our Rise Of The Entrepreneur page.

 

Working From Home: Is It the Future? [INFOGRAPHIC]

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Do you do your job remotely? Where do you work from – your house, office… bathroom?

Is it the future? This infographic by Staff.com tries to answer that question.

Takeaways:

• 1 in 4 US workers work from home.
• 73% of people who work from home eat healthier.
Richard Branson says people should be given the freedom to work where they want.

workfromhomefuture_infographic.jpg

For more information on great work from home options,
see our Rise Of The Entrepreneur page.

 

 

Can Your Finger Lengths Reveal Traits About Your Personality?

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Who would have thought you could learn so much about yourself based on your finger length? Above you’ll see three different hands labeled A, B, and C. With each one, the ring, middle and index finger are the lengths to compare. Put your left hand up and find the one that most closely matches you.

A) The charming but pragmatic one.

This one is me! People who have a ring finger longer than the index finger tend to be charming and irresistible to some at least. A’s are the ones who can talk themselves out of just about any situation. Additionally, they’re aggressive and excellent problem solvers. They tend to be incredibly compassionate and are often scientists, engineers, soldiers, and crossword puzzle masters.

B) The confident, get-it-done type.

People with shorter ring fingers than index fingers are the self-confident, get-it-done types. They love solitude in which to work and accomplish the things they need to do, but that doesn’t necessarily indicate introversion. They’re very goal oriented and don’t like to be disturbed. They appreciate what they have but often hunger for more.

C) The peacenik

C’s are the peace-loving conflict-avoiding types. People with even ring and index finger length are well organized and want nothing but to get along with everyone. They are faithful in relationships, tender and caring partners, but beware: C’s have a fiery core that while suppressed in normal day-to-day activities can be dangerous if unleashed. They might be peaceniks, but please, stay on their good side.

Which letter are you? Let’s hear your thoughts in the comments below!

Source: higherperspectives.com

Know These 7 Symbols On Plastic That May Poison You

Why is it that so many people won’t drink tap water, yet instead buy water, sport, and energy drinks bottled in plastic packaging?  Have you ever noticed that triangle and the number printed in the middle?

Why are so many people more interested in the water or liquid composition, if it is alkaline pH 9.0-10.0, etc., yet seem to gloss right over being interested in the chemical composition of the packaging that water comes in?

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At the bottom of every container or package, look for the triangle with the number in the middle to find out how dangerous the plastic may be for your health.

1 – PET (also PETE)
These bottles are intended for single use. They may leach heavy metal contaminants, and a chemical substance called BPA, which interferes with the function of our hormones. They may also be carcinogenic.

2 – HDP (also HDPE)
This is “good” plastic which has the lowest probability of leaching chemicals into the liquid it stores.

3 – PVC (also 3V)
Leaches toxic chemicals and both have influence on hormones in the human body. It is the most commonly used plastic.

4 – LDPE
Plastic which doesn’t leach chemicals.. Most commonly used for making plastic bags as well.

5 – PP
One of the “good” plastics, usually white or see through. It is used for containers of peanut butter, jelly, honey, syrup, yogurt cups, and other food sources.
(best to get glass containers if possible)

6 – PS
Contains carcinogenic styrene. Usually it is used for coffee cups or fast food packaging.

7 – PC (or no labeling)
This is the worst plastic for liquid and food products because it contains the chemical BPA. Unfortunately it is used in bottles for infants, sport and energy drinks and containers for food storage.

SUMMARY: The plastics numbered 2, 4 and 5 or the ones labeled HDP, HDPE and PP, don’t leach chemicals. The worst packaging has labels numbered 1, 3, 6 or 7. The liquid and food in these containers are subject to harsh chemical and temperature activity.

To add insult to injury, when these containers are re-filled for use, it’s contents are exposed to harmful bacterial contamination. DO NOT drink water or liquids that have been sitting in your car sunlight and heat — these are the worst!!

RECOMMENDATION: Learn more about the water you drink and shower/bathe in. Here are some great solutions you may want to check out for yourself.

Got 10 Minutes to Burn Your Belly Fat?

Are you one of those people who rarely go out, or make excuses that you cannot workout because of lack of time? If the answer is yes, than you are at the right place – for all these exercises you will need only 10 minutes and the best part is that you can do them at home.

HIIT or High Intensity Interval Training workout is interval training with high intensity, which is consisted of short exercises that will help you burn those calories quickly.

If you don’t have time to exercise this combination of exercises is ideal because it will take you only 10 minutes a day and you will manage to get rid of the excess calories. Even more, HIIT workout will accelerate your metabolism.

So move the couch, the table, play the video below and prepare to sweat!

Source: POPSUGAR Fitness

Resonance: Beings Of Frequency, EMF & DNA Impact

Resonance: Beings of Frequency, documentary film

We are “Beings of Frequency”

The earth has a heartbeat – a natural frequency that nurtures and sustains all life on this planet and which is absolutely integral to our mental and physical health.

Our cells, our brain and our DNA communicate using electromagnetic waves of frequency.  Our bodies not only produce these waves through the interaction of our own biology, but are susceptible to electromagnetic radiations that come from outside of our bodies in our environment.

“Resonance” is a documentary that sensationally reveals how we are being changed on a cellular level by our reliance on wireless technologies.

 

How Your Brain Works: Bruce Lipton, Your New Biology of Belief

it really is quite simple, once you understand all the connections.

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“You are personally responsible for everything in your life,
ONCE YOU BECOME AWARE THAT,
You are personally responsible for everything in your life!”

Here is Dr. Bruce H. Lipton, Ph.D, BIOLOGY OF BELIEF – Part 1/2


Be sure to visit our Beliefs, Perceptions, Memes page for more on these type of topics.

How Exercise Changes Expression Of Our DNA

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We all know that exercise can make us fitter and reduce our risk for illnesses such as diabetes and heart disease. But just how, from start to finish, a run or a bike ride might translate into a healthier life has remained baffling.

Now new research reports that the answer may lie, in part, in our DNA. Exercise, a new study finds, changes the shape and functioning of our genes, an important stop on the way to improved health and fitness.

The human genome is astonishingly complex and dynamic, with genes constantly turning on or off, depending on what biochemical signals they receive from the body. When genes are turned on, they express proteins that prompt physiological responses elsewhere in the body.

Scientists know that certain genes become active or quieter as a result of exercise. But they hadn’t understood how those genes know how to respond to exercise.


One-Legged Cycling:
David Corcoran, Jeffery DelViscio and Claire Maldarelli
Audio interview: Can exercise change our DNA?

scientists-admit-second-secret-DNA-code-controls-genes

Signals From Our Environment Control How DNA Expresses Our Genes

Enter epigenetics, a process by which the operation of genes is changed, but not the DNA itself. Epigenetic changes occur on the outside of the gene, mainly through a process called methylation. In methylation, clusters of atoms, called methyl groups, attach to the outside of a gene like microscopic mollusks and make the gene more or less able to receive and respond to biochemical signals from the body. (More info on Epigenetics here.)

Scientists know that methylation patterns change in response to lifestyle. Eating certain diets or being exposed to pollutants, for instance, can change methylation patterns on some of the genes in our DNA and affect what proteins those genes express. Depending on which genes are involved, it may also affect our health and risk for disease.

Far less has been known about exercise and methylation. A few small studies have found that a single bout of exercise leads to immediate changes in the methylation patterns of certain genes in muscle cells. But whether longer-term, regular physical training affects methylation, or how it does, has been unclear.

So for a study published this month in Epigenetics, scientists at the Karolinska Institute in Stockholm recruited 23 young and healthy men and women, brought them to the lab for a series of physical performance and medical tests, including a muscle biopsy, and then asked them to exercise half of their lower bodies for three months.

One of the obstacles in the past to precisely studying epigenetic changes has been that so many aspects of our lives affect our methylation patterns, making it difficult to isolate the effects of exercise from those of diet or other behaviors.

The Karolinska scientists overturned that obstacle by the simple expedient of having their volunteers bicycle using only one leg, leaving the other unexercised. In effect, each person became his or her own control group. Both legs would undergo methylation patterns influenced by his or her entire life; but only the pedaling leg would show changes related to exercise.

The volunteers pedaled one-legged at a moderate pace for 45 minutes, four times per week for three months. Then the scientists repeated the muscle biopsies and other tests with each volunteer.

Not surprisingly, the volunteers’ exercised leg was more powerful now than the other, showing that the exercise had resulted in physical improvements.

But the changes within the muscle cells’ DNA were more intriguing. Using sophisticated genomic analysis, the researchers determined that more than 5,000 sites on the genome of muscle cells from the exercised leg now featured new methylation patterns. Some showed more methyl groups; some fewer. But the changes were significant and not found in the unexercised leg.

Interestingly, many of the methylation changes were on portions of the genome known as enhancers that can amplify the expression of proteins by genes. And gene expression was noticeably increased or changed in thousands of the muscle-cell genes that the researchers studied.

Most of the genes in question are known to play a role in energy metabolism, insulin response and inflammation within muscles. In other words, they affect how healthy and fit our muscles — and bodies — become.

They were not changed in the unexercised leg.

The upshot is that scientists now better understand one more step in the complicated, multifaceted processes that make exercise so good for us.

Many mysteries still remain, though, said Malene Lindholm, a graduate student at the Karolinska Institute, who led the study. It’s unknown, for example, whether the genetic changes she and her colleagues observed would linger if someone quits exercising and how different amounts or different types of exercise might affect methylation patterns and gene expression. She and her colleagues hope to examine those questions in future studies.

The message of this study is unambiguous. “Through endurance training — a lifestyle change that is easily available for most people and doesn’t cost much money,” Ms. Lindholm said, “we can induce changes that affect how we use our genes and, through that, get healthier and more functional muscles that ultimately improve our quality of life.”